The frequency and time to use of these additional treatments were also determined. Pen back into the Carrying Case because that will damage the needle. And if you are like me, Never eat chocolate before bed!
Table 1 lists adverse reactions that occurred in 2 US placebo-controlled clinical trials in migraine patients Studies 2 and 3 following either a single 6-mg dose of Imitrex Injection or placebo. Know the medicines you take. Loi V, Lai M, Pisano MR, Delzompo M "Sumatriptan and panic-like symptoms. After using sumatriptan nasal spray, you must wait two 2 hours before using a second spray. Do not use more than 40 mg of sumatriptan nasal spray in 24 hours. What happens if I overdose? Embryolethality: When given intravenously to pregnant rabbits daily throughout the period of organogenesis, sumatriptan caused embryolethality at doses at or close to those producing maternal toxicity. The mechanism of the embryolethality is not known.
Injection in pregnant women. No gross overdoses in clinical practice have been reported. It may harm them. This information should not be used to decide whether or not to take Imitrex tablets or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about Imitrex tablets. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to Imitrex tablets. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your health care provider for complete information about the risks and benefits of using Imitrex tablets.
Medication overuse headache may present as migraine-like headaches or as a marked increase in frequency of migraine attacks. IMITREX Injection is contraindicated in patients with severe hepatic impairment. IMITREX Injection or Tablets. The efficacy of Imitrex Injection in the acute treatment of cluster headache was demonstrated in 2 randomized, double-blind, placebo-controlled, 2-period crossover trials Studies 4 and 5. Patients 21 to 65 years of age were enrolled and were instructed to treat a moderate to very severe headache within 10 minutes of onset. Headache relief was defined as a reduction in headache severity to mild or no pain.
The onset of symptoms generally occurs within minutes to hours of receiving a new or a greater dose of a serotoninergic medications. Ask your doctor or pharmacist about using this product safely. Storage requirements: The manufacturer's product information should be consulted. Sensations of tightness, pain, pressure, and heaviness in the precordium, throat, neck, and jaw commonly occur after treatment with Imitrex Tablets and are usually non-cardiac in origin. However, perform a cardiac evaluation if these patients are at high cardiac risk. The efficacy of Imitrex Tablets in the acute treatment of migraine headaches was demonstrated in 3, randomized, double-blind, placebo-controlled trials. Vagus nerve, since the headaches are immediately connected to the urge to have a bowel movement. As you age, it is normal to experience some memory lapses. Usually, an occasional memory lapse does not mean you have a serious problem. Defects in the corneal epithelium were noted in a 60-week study. Earlier examinations for these toxicities were not conducted and no-effect doses were not established; however, the relative exposure at the lowest dose tested was approximately 5 times the human exposure after a 100-mg oral dose or 3 times the human exposure after a 6-mg subcutaneous dose. Drink plenty of fluids as directed by your doctor to prevent and tell your doctor right away if you have a change in the amount of urine. If you are at high risk for heart disease, your doctor may want to check your heart before prescribing sumatriptan. What should I tell my healthcare provider before taking IMITREX? Important: The opinions expressed in WebMD User-generated content areas like communities, reviews, ratings, blogs, or WebMD Answers are solely those of the User, who may or may not have medical or scientific training. These opinions do not represent the opinions of WebMD. User-generated content areas are not reviewed by a WebMD physician or any member of the WebMD editorial staff for accuracy, balance, objectivity, or any other reason except for compliance with our Terms and Conditions. Respiratory: Bronchospasm in patients with and without a history of asthma. Prompt treatment allows you to get back to your normal routine and may decrease your need for other pain medications. Food and Drug Administration. Laboratory Test Interactions: IMITREX is not known to interfere with commonly employed clinical laboratory tests.
Overall, the frequency of adverse events reported in the studies of cluster headache were generally lower. Exceptions include reports of paresthesia 5% IMITREX, 0% placebo nausea and vomiting 4% IMITREX, 0% placebo and bronchospasm 1% IMITREX, 0% placebo. Product Information. Imitrex sumatriptan. Prinzmetal variant all forms of myocardial infarction, and silent myocardial ischemia. Cerebrovascular syndromes include, but are not limited to, strokes of any type as well as transient ischemic attacks. Use: For the acute treatment of cluster headache. What other drugs will affect sumatriptan? If you feel unwell in any other way or have any symptoms that you do not understand, you should contact your doctor immediately. IMITREX Injection is contraindicated. Do you have risk factors for heart disease such as high blood pressure, high cholesterol, obesity, diabetes, smoking, strong family history of heart disease, or you are postmenopausal or a male over 40? Remember that your doctor has prescribed this because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication not have serious side effects. General information about the safe and effective use of Imitrex. Take the Pen out of the Carrying Case. The vascular 5-HT 1 receptor subtype to which sumatriptan binds selectively, and through which it presumably exerts its antimigrainous effect, has been shown to be present on cranial arteries in both dog and primate, on the human basilar artery, and in the vasculature of the isolated dura mater of humans. In these tissues, sumatriptan activates this receptor to cause vasoconstriction, an action in humans correlating with the relief of migraine and cluster headache. In the anesthetized dog, sumatriptan selectively reduces the carotid arterial blood flow with little or no effect on arterial blood pressure or total peripheral resistance. In the cat, sumatriptan selectively constricts the carotid arteriovenous anastomoses while having little effect on blood flow or resistance in cerebral or extracerebral tissues. Carcinogenesis, Mutagenesis, Impairment of Fertility: In carcinogenicity studies, rats and mice were given sumatriptan by oral gavage rats, 104 weeks or drinking water mice, 78 weeks. Spierings EL "Intracranial hemorrhages associated with sumatriptan.
Musculoskeletal: Infrequent were various joint disturbances pain, stiffness, swelling, ache. Rare were muscle stiffness, need to flex calf muscles, backache, muscle tiredness, and swelling of the extremities. They work great if you have about four headaches per month, but for people with more you need a triptan. Imitrex is great for about two headaches per week, but anymore than that and you risk being like me. I am resistant to about everything. Follow all directions on your prescription label. Do not use this medicine in larger or smaller amounts or for longer than recommended. Overuse of migraine headache medicine can actually make your headaches worse. Life-threatening disturbances of cardiac rhythm, including ventricular tachycardia and ventricular fibrillation leading to death, have been reported within a few hours following the administration of 5-HT 1 agonists. Discontinue Imitrex Tablets if these disturbances occur. Imitrex Tablets are contraindicated in patients with Wolff-Parkinson-White syndrome or arrhythmias associated with other cardiac accessory conduction pathway disorders. The safety of treating an average of more than 4 headaches in a 30 day period has not been established. Gastrointestinal: Ischemic colitis with rectal bleeding see xerostomia. The effect of mild to moderate hepatic disease on the pharmacokinetics of subcutaneously administered sumatriptan has been evaluated. There were no significant differences in the pharmacokinetics of subcutaneously administered sumatriptan in moderately hepatically impaired subjects compared with healthy controls. The pharmacokinetics of subcutaneously administered sumatriptan in patients with severe hepatic impairment has not been studied. She prescribed Compazine Prochlorperazine.
If you are taking a liquid product, use a medication-measuring device to carefully measure the dose. Do not use a household spoon. Some liquid products need to be shaken before each dose. Some products that contain need to be placed under the and held there before swallowing. Follow label directions carefully to get the most benefit. Curtin T, Brooks AP, Roberts JA "Cardiorespiratory distress after sumatriptan given by injection. You should write down when you have headaches and when you take Imitrex so you can talk with your healthcare provider about how Imitrex is working for you. Imitrex spray is to be used only by the patient for whom it is prescribed. Do not share it with other people. Dachs R, Vitillo J "Angioedema associated with sumatriptan administration. Some people who use too many Imitrex tablets may have worse headaches medication overuse headache. If your headaches get worse, your healthcare provider may decide to stop your treatment with Imitrex. Taking MAO inhibitors with this medication may cause a serious possibly fatal drug interaction. Do not take any MAO inhibitors isocarboxazid, linezolid, methylene blue, moclobemide, phenelzine, procarbazine, rasagiline, selegiline, tranylcypromine during treatment with this medication. Most MAO inhibitors should also not be taken for two weeks before treatment with this medication. Ask your doctor when to start or stop taking this medication. HT 1 agonists. Since visual disorders may be part of a migraine attack, a causal relationship between these events and the use of 5-HT 1 agonists have not been clearly established.
Have you had a stroke, transient ischemic attacks TIAs or Raynaud syndrome? Imitrex spray is not approved for use in CHILDREN younger than 18 years old. Talk with the doctor. The goal: Choose what works, use it first, and use it fast. Dogs receiving oral sumatriptan developed corneal opacities and defects in the corneal epithelium. Oral treatment of pregnant rats with sumatriptan during the latter part of gestation and throughout lactation resulted in a decrease in pup survival. Severe allergic reactions rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue; bloody diarrhea; burning or aching in your feet or toes; burning, numbness, or tingling; constipation; diarrhea; fainting; feeling or heaviness or tightness in your leg muscles; fever; hearing problems; leg cramps; seizures; severe or persistent headache, dizziness, nausea, or vomiting; severe stomach pain; very cold or blue fingers or toes; vision changes or loss of vision; weight loss; wheezing. Five controlled clinical trials 2 single attack studies, 3 multiple attack studies evaluating oral sumatriptan 25 to 100 mg in pediatric patients aged 12 to 17 years enrolled a total of 701 adolescent migraineurs. These studies did not establish the efficacy of oral sumatriptan compated to placebo in the treatment of migraine in adolescents. Adverse events observed in these clinical trials were similar in nature to those reported in clinical trials in adults. The frequency of all adverse events in these patients appeared to be both dose- and age-dependent, with younger patients reporting events more commonly than older adolescents. Local irritative symptoms were reported in clinical trials with sumatriptan nasal spray in approximately 5% of patients, and were severe in about 1% of cases. Symptoms were noted as being transient and generally resolved in less than 2 hours. Imitrex Injection also relieved photophobia, phonophobia sound sensitivity nausea, and vomiting associated with migraine attacks. Similar efficacy was seen when patients self-administered Imitrex Injection using the IMITREX STATdose Pen. IMITREX Injection is contraindicated in patients with hypersensitivity to sumatriptan or any of its components. What is the most important information I should know about Imitrex? Aspirin and other nonsteroidal anti-inflammatory drugs also can help if you take them at the first sign of a migraine attack. NSAIDs also include ibuprofen and naproxen. IMITREX STATdose Pen. Visually inspect the vial for particulate matter and discoloration before administration. Do not use if particulates and discolorations are noted. The pain is almost always one-sided, and it stays on the same side during a period, the time when you're getting daily attacks. When a new headache period starts, it might switch to the opposite side, but that's rare. Do not flush down the toilet or pour them into a drain unless instructed to do so. Properly discard this product when it is expired or no longer needed. Consult your pharmacist or local waste disposal company.
The injection is intended to be given subcutaneously, and intramuscular or intravascular delivery must be avoided. Instruct patients on the proper use of IMITREX STATdose Pen and direct them to use injection sites with an adequate skin and subcutaneous thickness to accommodate the length of the needle. IMITREX can cause dizziness, weakness, or drowsiness. If you have these symptoms, do not drive a car, use machinery, or do anything where you need to be alert. This medication has been prescribed for your current condition only. Do not use it later for another condition unless your doctor directs you to do so. A different medication may be necessary in that case. The trials did not establish the efficacy of IMITREX Nasal Spray compared with placebo in the treatment of migraine in pediatric patients. Adverse reactions observed in these clinical trials were similar in nature to those reported in clinical trials in adults. Try these drugs first. Your blood pressure will need to be checked often. Lab tests, including heart function tests, may be performed while you use Imitrex spray. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments. This Patient Information leaflet summarizes the most important information about IMITREX. If you would like more information, talk with your healthcare provider. You can ask your healthcare provider or pharmacist for information about IMITREX that is written for healthcare professionals. Imitrex Injection. Such reactions can be life threatening or fatal. Some MEDICINES MAY INTERACT with Imitrex spray. The fact that sumatriptan can cause coronary vasospasm, that some of these events have occurred in patients with no prior cardiac disease history and with documented absence of CAD, and the close proximity of the events to sumatriptan use support the conclusion that some of these cases were caused by the drug. In many cases, however, where there has been known underlying CAD, the relationship is uncertain. Oral sumatriptan has not been evaluated for race differences. Five controlled clinical trials 2 single-attack trials, 3 multiple-attack trials evaluating oral IMITREX 25 to 100 mg in pediatric patients 12 to 17 years of age enrolled a total of 701 pediatric migraineurs. These trials did not establish the efficacy of oral IMITREX compared with placebo in the treatment of migraine in pediatric patients. Adverse reactions observed in these clinical trials were similar in nature to those reported in clinical trials in adults. The frequency of all adverse reactions in these patients appeared to be both dose- and age-dependent, with younger patients reporting reactions more commonly than older pediatric patients. Such reactions can be life threatening or fatal.
Food and Drug Administration. WebMD does not endorse any specific product, service or treatment. After each use the Pen must be put back into the Carrying Case to reset the white Priming Rod before the next use. Do not dispose of your used sharps disposal container in your household trash unless your community guidelines permit this. Do not recycle your used sharps disposal container. Case to reset the white Priming before the next use. How often do you have them? The name of your medicine is IMITREX sumatriptan succinate Injection. It can be obtained only by prescription from your doctor. The decision to use IMITREX Injection is one that you and your doctor should make jointly, taking into account your individual preferences and medical circumstances. If you have risk factors for heart disease such as high blood pressure, high cholesterol, obesity, diabetes, smoking, strong family history of heart disease, or you are postmenopausal or a male over 40 you should tell your doctor, who should evaluate you for heart disease in order to determine if IMITREX is appropriate for you. Although the vast majority of those who have taken IMITREX have not experienced any significant side effects, some individuals have experienced serious heart problems and, rarely, considering the extensive use of IMITREX worldwide, deaths have been reported. In all but a few instances, however, serious problems occurred in people with known heart diseases and it was not clear whether IMITREX was a contributory factor in these deaths.
Pen as shown in Figure B before you load a new Syringe Cartridge. It has helped tremendously. The headaches have lessened. Serious and sometimes fatal brain blood vessel problems like stroke have rarely happened with Imitrex tablets. Contact your doctor at once if you have confusion, one-sided weakness, or speech or vision changes. Do not touch this area again before giving the injection. IMITREX STAT dose System NDC 0173-0739-02. IMITREX is not used to prevent or decrease the number of migraine or cluster headaches you have. Drug Interactions: There is no evidence that concomitant use of migraine prophylactic medications has any effect on the efficacy of sumatriptan.
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IMITREX STATdose System NDC 0173-0478-00. Use: For the acute treatment of migraine with or without aura. Before you use IMITREX STATdose System your healthcare provider should show you or your caregiver how to give an injection the right way.
Cardiovascular: Abdominal aortic aneurysm, angina, atherosclerosis, cerebral ischemia, cerebrovascular lesion, heart block, peripheral cyanosis, phlebitis, thrombosis, and transient myocardial ischemia. Some patients experience pain or tightness in the chest or throat when using IMITREX Injection. If this happens to you, then discuss it with your doctor before using any more IMITREX Injection. If the chest pain is severe or does not go away, call your doctor immediately. Do not touch the Blue Button until you have pressed the Pen firmly against your skin to give a dose. Treatment of migraine attacks with sumatriptan. the subcutaneous sumatriptan international study group.
Do not consider WebMD User-generated content as medical advice. Never delay or disregard seeking professional medical advice from your doctor or other qualified healthcare provider because of something you have read on WebMD. You should always speak with your doctor before you start, stop, or change any prescribed part of your care plan or treatment. WebMD understands that reading individual, real-life experiences can be a helpful resource but it is never a substitute for professional medical advice, diagnosis, or treatment from a qualified health care provider. If you think you may have a medical emergency, call your doctor or dial 911 immediately.
Sumatriptan may also be used for purposes not listed in this medication guide. What is the most important information I should know about sumatriptan? AMERGE, IMITREX, IMITREX STATdose System, and IMITREX STATdose Pen are registered trademarks of the GSK group of companies. The other brands listed are trademarks of their respective owners and are not trademarks of the GSK group of companies. The makers of these brands are not affiliated with and do not endorse the GSK group of companies or its products. Some medical conditions may interact with Imitrex spray.